GJ103 sodium salt (Cat.No:I006967) is an active analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations.
| Catalog Number | I006967 |
| CAS Number | 1459687-96-7 (sodium) |
| Synonyms | GJ-103 sodium;;sodium 2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetate |
| Molecular Formula | C16H13N4NaO3S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | sodium;2-[[4-(3-methoxyphenyl)-5-pyridin-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetate |
| InChI | InChI=1S/C16H14N4O3S.Na/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22;/h2-9H,10H2,1H3,(H,21,22);/q;+1/p-1 |
| InChIKey | PTFQBXAUOWUATD-UHFFFAOYSA-M |
| SMILES | COC1=CC=CC(=C1)N2C(=NN=C2SCC(=O)[O-])C3=CC=CC=N3.[Na+] |
| Reference | </br>1:Management of untreatable ventricular arrhythmias during pharmacologic challenges with sodium channel blockers for suspected Brugada syndrome. Poli S, Toniolo M, Maiani M, Zanuttini D, Rebellato L, Vendramin I, Dametto E, Bernardi G, Bassi F, Napolitano C, Livi U, Proclemer A.Europace. 2017 May 17. doi: 10.1093/europace/eux092. [Epub ahead of print] PMID: 28521022 </br>2:Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy. Holland KD, Bouley TM, Horn PS.Epilepsia. 2017 May 18. doi: 10.1111/epi.13798. [Epub ahead of print] PMID: 28518218 </br>3:Ag-Catalyzed Oxidative Cyclization Reaction of 1,6-Enynes and Sodium Sulfinate: Access to Sulfonylated Benzofurans. Wu W, Yi S, Huang W, Luo D, Jiang H.Org Lett. 2017 May 18. doi: 10.1021/acs.orglett.7b00980. [Epub ahead of print] PMID: 28517933 </br>4:Sodium-Glucose Co-transporter-2 Inhibitors and Diabetic Ketoacidosis. An Updated Review of the Literature. Bonora BM, Avogaro A, Fadini GP.Diabetes Obes Metab. 2017 May 18. doi: 10.1111/dom.13012. [Epub ahead of print] Review. PMID: 28517913 </br>5:Effects of calcineurin inhibitors on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation. Saburi M, Kohashi S, Kato J, Koda Y, Sakurai M, Toyama T, Kikuchi T, Karigane D, Yuda S, Yamane Y, Hashida R, Abe R, Nakazato T, Hirahashi J, Ogata M, Okamoto S, Mori T.Int J Hematol. 2017 May 17. doi: 10.1007/s12185-017-2253-x. [Epub ahead of print] PMID: 28516402 </br>6:Intracellular morphological changes in Staphylococcus aureus induced by treatment with sodium hypochlorite. Ujimine S, Tone S, Saito M, Yamada S.Med Mol Morphol. 2017 May 17. doi: 10.1007/s00795-017-0159-6. [Epub ahead of print] PMID: 28516285 </br>7:GPNA inhibits the sodium-independent transport system L for neutral amino acids. Chiu M, Sabino C, Taurino G, Bianchi MG, Andreoli R, Giuliani N, Bussolati O.Amino Acids. 2017 May 17. doi: 10.1007/s00726-017-2436-z. [Epub ahead of print] PMID: 28516268 </br>8:Effects of phosalone consumption via feeding with or without sodium bentonite on performance, blood metabolites and its transition to milk of Iranian Baluchi sheep. Kazemi M, Torbaghan AE, Tahmasbi AM, Valizadeh R, Naserian AA.J Anim Sci Technol. 2017 May 15;59:10. doi: 10.1186/s40781-017-0135-7. eCollection 2017. PMID: 28515956 Free Article</br>9:Functional Assessment of Sodium Chloride Co-transporter NCC Mutants in Polarized Mammalian Epithelial Cells. Rosenbaek LL, Rizzo F, MacAulay N, Staub O, Fenton RA.Am J Physiol Renal Physiol. 2017 May 17:ajprenal.00088.2017. doi: 10.1152/ajprenal.00088.2017. [Epub ahead of print] PMID: 28515174 </br>10:Comparative Antimicrobial Efficacy of <i>Eucalyptus Galbie</i> and <i>Myrtus Communis L.</i> Extracts, Chlorhexidine and Sodium Hypochlorite against <i>Enterococcus Faecalis</i>. Nourzadeh M, Amini A, Fakoor F, Raoof M, Sharififar F.Iran Endod J. 2017 Spring;12(2):205-210. doi: 10.22037/iej.2017.40. PMID: 28512487 Free PMC Article |
