For research use only. Not for therapeutic Use.
Glaucocalyxin B（Cat No.:I013735）, an enantio-kaurane-type diterpene from Xiangchacai, exhibits anticancer and anti-inflammatory properties. It demonstrates an IC50 value of approximately 5.86 μM in inhibiting the growth of HL-60 cells within 24 hours. This compound shows promise as a potential therapeutic agent, but further research is necessary to explore its mechanisms of action and evaluate its efficacy and safety for clinical applications.
| Catalog Number | I013735 |
| CAS Number | 80508-81-2 |
| Molecular Formula | C₂₂H₃₀O₅ |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | DMSO |
| Storage | Store at -20°C |
| IUPAC Name | [(1R,2R,4S,9R,10S,13S,16R)-2-hydroxy-5,5,9-trimethyl-14-methylidene-6,15-dioxo-16-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate |
| InChI | InChI=1S/C22H30O5/c1-11-13-6-7-14-21(5)9-8-16(24)20(3,4)15(21)10-17(25)22(14,18(11)26)19(13)27-12(2)23/h13-15,17,19,25H,1,6-10H2,2-5H3/t13-,14-,15+,17+,19+,21-,22-/m0/s1 |
| InChIKey | LSUXOKVMORWDLT-KEXKRWMXSA-N |
| SMILES | CC(=O)OC1C2CCC3C1(C(CC4C3(CCC(=O)C4(C)C)C)O)C(=O)C2=C |
| Reference | [1]. Yang WH, et al. Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells. Anticancer Agents Med Chem. 2013 Oct;13(8):1280-90.<br>[2]. Pan Y, et al. Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells. Mol Med Rep. 2016 Aug;14(2):1751-5.<br>[3]. Gan P, et al. Anti-inflammatory effects of glaucocalyxin B in microglia cells. J Pharmacol Sci. 2015 May;128(1):35-46. |
