For research use only. Not for therapeutic Use.
Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2].
Glemanserin (MDL11939) suppresses the induced increase in locomotor activity, behavioral sensitization and withdrawal symptoms in male mice[1].
| Catalog Number | M008390 |
| CAS Number | 107703-78-6 |
| Synonyms | phenyl-[1-(2-phenylethyl)piperidin-4-yl]methanol |
| Molecular Formula | C20H25NO |
| Purity | ≥95% |
| InChI | InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2 |
| InChIKey | AXNGJCOYCMDPQG-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1C(C2=CC=CC=C2)O)CCC3=CC=CC=C3 |
| Reference | [1]. Pehek EA, et al. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology. 2006;31(2):265-277. |
