For research use only. Not for therapeutic Use.
Gliquidone is an ATP-dependent K+ (KATP) channel blocker. Gliquidone is an anti-diabetic drug in the sulfonylurea class. Gliquidone is used in the treatment of diabetes mellitus type 2. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx and eventually increases insulin release.
| Catalog Number | A001106 |
| CAS Number | 33342-05-1 |
| Synonyms | Glurenorm |
| Molecular Formula | C27H33N3O6S |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | >22.4mg/mL in DMSO |
| Storage | 3 years -20C powder |
| Reference | </br>1:The effect of gliquidone on KATP channels in pancreatic β-cells, cardiomyocytes, and vascular smooth muscle cells. Liu SY, Tian HM, Liao DQ, Chen YF, Gou ZP, Xie XY, Li XJ.Diabetes Res Clin Pract. 2015 Aug;109(2):334-9. doi: 10.1016/j.diabres.2015.05.036. Epub 2015 May 18. PMID: 26044612 </br>2:Gliquidone versus metformin: differential effects on aorta in streptozotocin induced diabetic rats. Tan Z, Xu Z, Gui Q, Wu W, Yang Y.Chin Med J (Engl). 2014;127(7):1298-303. PMID: 24709184 </br>3:Gliquidone decreases urinary protein by promoting tubular reabsorption in diabetic Goto-Kakizaki rats. Ke JT, Li M, Xu SQ, Zhang WJ, Jiang YW, Cheng LY, Chen L, Lou JN, Wu W.J Endocrinol. 2014 Jan 8;220(2):129-41. doi: 10.1530/JOE-13-0199. Print 2014 Feb. PMID: 24254365 Free Article</br>4:Pharmacokinetics and hepatic uptake of gliquidone affected by Huangqi injection. Zhang F, Wei Y, Zhou Y, Wang D, Zhou L, Zhang J, Wu X.Eur J Drug Metab Pharmacokinet. 2014 Dec;39(4):255-61. doi: 10.1007/s13318-013-0154-9. Epub 2013 Oct 2. PMID: 24085486 </br>5:Contribution of cytochrome P450 isoforms to gliquidone metabolism in rats and human. He F, Li Y, Zeng C, Xia C, Xiong Y, Zhang H, Huang S, Liu M.Xenobiotica. 2014 Mar;44(3):229-34. doi: 10.3109/00498254.2013.831957. Epub 2013 Aug 29. PMID: 23987740 </br>6:RP-LC method for the simultaneous determination of gliquidone, pioglitazone hydrochloride, and atorvastatin in formulations and human serum. Mirza AZ, Arayne MS, Sultana N.J AOAC Int. 2013 Jan-Feb;96(1):56-9. PMID: 23513958 </br>7:Gliquidone. Gelbrich T, Haddow MF, Griesser UJ.Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1343. doi: 10.1107/S1600536811016680. Epub 2011 May 7. PMID: 21754738 Free PMC Article</br>8:Simultaneous determination of gliquidone, pioglitazone hydrochloride, and verapamil in formulation and human serum by RP-HPLC. Arayne MS, Sultana N, Mirza AZ.J Chromatogr Sci. 2011 Feb;49(2):114-7. PMID: 21223635 </br>9:Simultaneous determination of gliquidone, fexofenadine, buclizine, and levocetirizine in dosage formulation and human serum by RP-HPLC. Arayne MS, Sultana N, Mirza AZ, Siddiqui FA.J Chromatogr Sci. 2010 May-Jun;48(5):382-5. PMID: 20515533 </br>10:Gliquidone therapy of new-onset diabetes mellitus after kidney transplantation. Tuerk TR, Bandur S, Nuernberger J, Kribben A, Mann K, Philipp T, Heemann U, Viklicky O, Witzke O.Clin Nephrol. 2008 Jul;70(1):26-32. PMID: 18793545 |
