Globomycin

For research use only. Not for therapeutic Use.

  • CAT Number: I016736
  • CAS Number: 67076-74-8
  • Molecular Formula: C₃₂H₅₇N₅O₉
  • Molecular Weight: 655.82
  • Purity: ≥95%
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Globomycin(Cat No.:I016736)is a peptide antibiotic known for its specific inhibition of lipoprotein signal peptidase (LspA) in gram-negative bacteria. By blocking LspA, Globomycin disrupts the maturation of lipoproteins, essential for bacterial cell membrane function, leading to cell death. This mechanism makes it valuable in researching novel antibacterial strategies, particularly against resistant strains. Globomycin’s unique target specificity aids studies on bacterial membrane processes and lipoprotein function, offering potential pathways for developing targeted antibiotics to combat infections caused by gram-negative pathogens in clinical and pharmaceutical research.


Catalog Number I016736
CAS Number 67076-74-8
Molecular Formula C₃₂H₅₇N₅O₉
Purity ≥95%
Storage -20°C
IUPAC Name 12-butan-2-yl-19-hexyl-6-(1-hydroxyethyl)-9-(hydroxymethyl)-16,18-dimethyl-15-(2-methylpropyl)-1-oxa-4,7,10,13,16-pentazacyclononadecane-2,5,8,11,14,17-hexone
InChI InChI=1S/C32H57N5O9/c1-9-11-12-13-14-24-20(6)32(45)37(8)23(15-18(3)4)29(42)35-26(19(5)10-2)31(44)34-22(17-38)28(41)36-27(21(7)39)30(43)33-16-25(40)46-24/h18-24,26-27,38-39H,9-17H2,1-8H3,(H,33,43)(H,34,44)(H,35,42)(H,36,41)
InChIKey VFGBXFZXJAWPOE-UHFFFAOYSA-N
SMILES CCCCCCC1C(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)O1)C(C)O)CO)C(C)CC)CC(C)C)C)C
Reference

[1]. Béven L, et al. Inhibition of spiralin processing by the lipopeptide antibiotic globomycin. Curr Microbiol. 1996 Nov;33(5):317-22.<br>[2]. Parthasarathy S, et al. Organophosphate Hydrolase Is a Lipoprotein and Interacts with Pi-specific Transport System to Facilitate Growth of Brevundimonas diminuta Using OP Insecticide as Source of Phosphate. J Biol Chem. 2016 Apr 1;291(14):7774-85.

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