For research use only. Not for therapeutic Use.
Globomycin（Cat No.:I016736）is a peptide antibiotic known for its specific inhibition of lipoprotein signal peptidase (LspA) in gram-negative bacteria. By blocking LspA, Globomycin disrupts the maturation of lipoproteins, essential for bacterial cell membrane function, leading to cell death. This mechanism makes it valuable in researching novel antibacterial strategies, particularly against resistant strains. Globomycin’s unique target specificity aids studies on bacterial membrane processes and lipoprotein function, offering potential pathways for developing targeted antibiotics to combat infections caused by gram-negative pathogens in clinical and pharmaceutical research.
| Catalog Number | I016736 |
| CAS Number | 67076-74-8 |
| Molecular Formula | C₃₂H₅₇N₅O₉ |
| Purity | ≥95% |
| Target | Bacterial |
| Storage | -20°C |
| IUPAC Name | 12-butan-2-yl-19-hexyl-6-(1-hydroxyethyl)-9-(hydroxymethyl)-16,18-dimethyl-15-(2-methylpropyl)-1-oxa-4,7,10,13,16-pentazacyclononadecane-2,5,8,11,14,17-hexone |
| InChI | InChI=1S/C32H57N5O9/c1-9-11-12-13-14-24-20(6)32(45)37(8)23(15-18(3)4)29(42)35-26(19(5)10-2)31(44)34-22(17-38)28(41)36-27(21(7)39)30(43)33-16-25(40)46-24/h18-24,26-27,38-39H,9-17H2,1-8H3,(H,33,43)(H,34,44)(H,35,42)(H,36,41) |
| InChIKey | VFGBXFZXJAWPOE-UHFFFAOYSA-N |
| SMILES | CCCCCCC1C(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)O1)C(C)O)CO)C(C)CC)CC(C)C)C)C |
| Reference | [1]. Béven L, et al. Inhibition of spiralin processing by the lipopeptide antibiotic globomycin. Curr Microbiol. 1996 Nov;33(5):317-22.<br>[2]. Parthasarathy S, et al. Organophosphate Hydrolase Is a Lipoprotein and Interacts with Pi-specific Transport System to Facilitate Growth of Brevundimonas diminuta Using OP Insecticide as Source of Phosphate. J Biol Chem. 2016 Apr 1;291(14):7774-85. |
