GLP-1R modulator C16

• CAT Number: I045234
• CAS Number: 875005-43-9
• Molecular Formula: C21H26ClFN2O3
• Molecular Weight: 408.89
• Purity: ≥95%
• Synonyms: N-[[4-[(2-chloro-6-fluorophenyl)methoxy]-3-methoxyphenyl]methyl]-2-morpholin-4-ylethanamine
• InChI: InChI=1S/C21H26ClFN2O3/c1-26-21-13-16(14-24-7-8-25-9-11-27-12-10-25)5-6-20(21)28-15-17-18(22)3-2-4-19(17)23/h2-6,13,24H,7-12,14-15H2,1H3
• InChIKey: PQAPAXXUERVALT-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)CNCCN2CCOCC2)OCC3=C(C=CC=C3Cl)F

GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).

Reference

[1]. Wang J, et al. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site. ACS Chem Biol. 2021 Nov 19;16(11):2444-2452.
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