GLP-1R modulator C5

• CAT Number: I045233
• CAS Number: 421578-93-0
• Molecular Formula: C24H21NO3
• Molecular Weight: 371.43
• Purity: ≥95%
• Synonyms: 3-hydroxy-3-phenacyl-1-(2-phenylethyl)indol-2-one
• InChI: InChI=1S/C24H21NO3/c26-22(19-11-5-2-6-12-19)17-24(28)20-13-7-8-14-21(20)25(23(24)27)16-15-18-9-3-1-4-10-18/h1-14,28H,15-17H2
• InChIKey: QSAOBVACSHPJMW-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CCN2C3=CC=CC=C3C(C2=O)(CC(=O)C4=CC=CC=C4)O

GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM).

Reference

[1]. Wang J, et al. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site. ACS Chem Biol. 2021 Nov 19;16(11):2444-2452.
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