GLP-1R modulator L7-028

• CAT Number: I045231
• CAS Number: 2648317-95-5
• Molecular Formula: C24H28N2O3
• Molecular Weight: 392.49
• Purity: ≥95%
• Synonyms: 3-cyclopentyloxy-N-[3-(piperidine-1-carbonyl)phenyl]benzamide
• InChI: InChI=1S/C24H28N2O3/c27-23(18-8-7-13-22(17-18)29-21-11-2-3-12-21)25-20-10-6-9-19(16-20)24(28)26-14-4-1-5-15-26/h6-10,13,16-17,21H,1-5,11-12,14-15H2,(H,25,27)
• InChIKey: QASJOTNVPCHDTC-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)C(=O)C2=CC(=CC=C2)NC(=O)C3=CC(=CC=C3)OC4CCCC4

GLP-1R modulator L7-028 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM).

Reference

[1]. Wang J, et al. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site. ACS Chem Biol. 2021 Nov 19;16(11):2444-2452.
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