GLP-26

• CAT Number: I018128
• CAS Number: 2133017-36-2
• Molecular Formula: C₁₉H₁₇F₂N₃O₃
• Molecular Weight: 373.35
• Purity: ≥95%
• IUPAC Name: N-(3,4-difluorophenyl)-1,3,5-trimethyl-4-[2-oxo-2-(prop-2-ynylamino)acetyl]pyrrole-2-carboxamide
• InChI: InChI=1S/C19H17F2N3O3/c1-5-8-22-19(27)17(25)15-10(2)16(24(4)11(15)3)18(26)23-12-6-7-13(20)14(21)9-12/h1,6-7,9H,8H2,2-4H3,(H,22,27)(H,23,26)
• InChIKey: SQOFSIXYJGPNKV-UHFFFAOYSA-N
• SMILES: CC1=C(N(C(=C1C(=O)C(=O)NCC#C)C)C)C(=O)NC2=CC(=C(C=C2)F)F

GLP-26（Cat No.:I018128）is a hepatitis B virus (HBV) capsid assembly modulator (CAM) that inhibits HBV DNA replication with an IC₅₀ of 3 nM in the HepAD38 system.At a concentration of 1 μM, it reduces covalently closed circular DNA (cccDNA) by over 90%. GLP-26 disrupts the encapsidation of pre-genomic RNA, leading to nucleocapsid disassembly and a decrease in cccDNA pools. Additionally, it contains an alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules, making it useful in click chemistry applications.

Reference

[1]. Nijampatnam B, et al. Recent advances in the development of HBV capsid assembly modulators. Curr Opin Chem Biol. 2019 Jun;50:73-79.