For research use only. Not for therapeutic Use.
GLPG0492 (Cat.No:I000806) is a chemical compound developed for potential therapeutic use. It is an inhibitor of the enzyme autotaxin, which plays a role in various biological processes. GLPG0492 has shown promise in preclinical studies for its anti-inflammatory and anti-fibrotic properties, making it a candidate for the treatment of fibrotic diseases and inflammatory conditions.
| Catalog Number | I000806 |
| CAS Number | 1215085-92-9 |
| Molecular Formula | C19H14F3N3O3 |
| Purity | ≥95% |
| Target | Androgen Receptor |
| Solubility | 10 mM in DMSO |
| Storage | Store at RT |
| IUPAC Name | 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
| InChI | InChI=1S/C19H14F3N3O3/c1-24-17(28)25(14-8-7-12(10-23)15(9-14)19(20,21)22)16(27)18(24,11-26)13-5-3-2-4-6-13/h2-9,26H,11H2,1H3/t18-/m1/s1 |
| InChIKey | VAJGULUVTFDTAS-GOSISDBHSA-N |
| SMILES | N#CC1=CC=C(N(C(N(C)[C@]2(CO)C3=CC=CC=C3)=O)C2=O)C=C1C(F)(F)F |
| Reference | </br>1:Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization. Blanqué R, Lepescheux L, Auberval M, Minet D, Merciris D, Cottereaux C, Clément-Lacroix P, Delerive P, Namour F.BMC Musculoskelet Disord. 2014 Sep 3;15:291. doi: 10.1186/1471-2474-15-291. PMID: 25185887 Free PMC Article</br>2:GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Cozzoli A, Capogrosso RF, Sblendorio VT, Dinardo MM, Jagerschmidt C, Namour F, Camerino GM, De Luca A.Pharmacol Res. 2013 Jun;72:9-24. doi: 10.1016/j.phrs.2013.03.003. Epub 2013 Mar 22. PMID: 23523664 |
