For research use only. Not for therapeutic Use.
GLPG0634 analog (Compoun 176) is a broad spectrum JAK inhibitor with IC50 values of <100 nM against JAK1, JAK2 and JAK3[1].
GLPG0634 analog (Compoun 176) inhibits JAK-STAT signaling and OSM/IL-lβ signaling with both EC50 values of 101-500 nM[1].
GLPG0634 analog shows microsomal stability of 76%-100% in rat and human[1].
| Catalog Number | I000760 |
| CAS Number | 1206101-20-3 |
| Synonyms | N-[5-[4-[(6-cyanopyridin-3-yl)methoxy]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide |
| Molecular Formula | C23H18N6O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30) |
| InChIKey | QZXABVVSCDZCLR-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)OCC5=CN=C(C=C5)C#N |
| Reference | [1]. Christel Jeanne Marie Menet, et al. Novel compounds useful for the treatment of degenerative and inflammatory diseases. WO2010010190A1. |
