Glucagon (1-29), bovine, human, porcine hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I015409
  • CAS Number: 28270-04-4
  • Molecular Formula: C₁₅₃H₂₂₅N₄₃O₄₉S.ClH
  • Molecular Weight: 3519.21
  • Purity: ≥95%
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Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis[1]. Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation[2][3].<br>Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia[1].
Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis[1].
Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes[3].
Glucagon (100 nM) increases phosphorylayion of HNF4α[3].<br>Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice[4].


Catalog Number I015409
CAS Number 28270-04-4
Molecular Formula C₁₅₃H₂₂₅N₄₃O₄₉S.ClH
Purity ≥95%
Target GCGR
Reference

[1]. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81.<br>[2]. Hirota K, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003 Apr 11;278(15):13056-60.<br>[3]. Song KH, et al. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in humanhepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology. 2006 Jan;43(1):117-25.<br>[4]. Capozzi ME, et al. Glucagon lowers glycemia when β-cells are active. JCI Insight. 2019 Jul 23;5. pii: 129954.

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