Glucagon

• CAT Number: I002209
• CAS Number: 16941-32-5
• Molecular Formula: C153H225N43O49S
• Molecular Weight: 3482.75
• Purity: ≥95%
• Target: GCGR
• Solubility: H2O
• Storage: Store at -20C

Glucagon(CAT: I002209) is a peptide hormone that plays a crucial role in regulating glucose metabolism. It is primarily produced by the alpha cells of the pancreas and acts as a counter-regulatory hormone to insulin. Glucagon acts on the liver to stimulate the breakdown of glycogen into glucose, thus increasing blood glucose levels. It also promotes gluconeogenesis, the synthesis of glucose from non-carbohydrate sources, and enhances fatty acid oxidation. Due to its ability to raise blood glucose levels, glucagon has therapeutic potential in the management of certain metabolic diseases, such as hypoglycemia and certain types of diabetes.

Reference

1:Erratum to: Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) in the Brain-Adipocyte Axis. Geloneze B, de Lima-Júnior JC, Velloso LA.Drugs. 2017 May 18. doi: 10.1007/s40265-017-0766-5. [Epub ahead of print] No abstract available. PMID: 28523587
2:A DPP-IV-resistant glucagon-like peptide-2 dimer with enhanced activity against radiation-induced intestinal injury. Gu J, Liu S, Mu N, Huang T, Zhang W, Zhao H, Shu Z, Zhang C, Hao Q, Li W, Xue X, Zhang W, Zhang Y.J Control Release. 2017 May 15. pii: S0168-3659(17)30592-8. doi: 10.1016/j.jconrel.2017.05.020. [Epub ahead of print] PMID: 28522195
3:Exaggerated glucagon responses to hypoglycemia in women with polycystic ovary syndrome. Sam S, Vellanki P, Yalamanchi SK, Bergman RN, Dunaif A.Metabolism. 2017 Jun;71:125-131. doi: 10.1016/j.metabol.2017.03.008. Epub 2017 Mar 22. PMID: 28521865
4:The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms. Zhao C, Liang J, Yang Y, Yu M, Qu X.Front Endocrinol (Lausanne). 2017 May 3;8:98. doi: 10.3389/fendo.2017.00098. eCollection 2017. Review. PMID: 28515711 Free Article
5:Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. Lv S, Qiu X, Li J, Liang J, Li W, Zhang C, Zhang Z, Luan B.J Endocrinol. 2017 May 17. pii: JOE-16-0649. doi: 10.1530/JOE-16-0649. [Epub ahead of print] PMID: 28515141
6:Human Epicardial Fat Expresses Glucagon-Like Peptide 1 and 2 Receptors Genes. Iacobellis G, Camarena V, Sant DW, Wang G.Horm Metab Res. 2017 May 17. doi: 10.1055/s-0043-109563. [Epub ahead of print] PMID: 28514806
7:Structure of the full-length glucagon class B G-protein-coupled receptor. Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B.Nature. 2017 May 17. doi: 10.1038/nature22363. [Epub ahead of print] PMID: 28514451
8:Population pharmacokinetics of lyophilized recombinant glucagon-like peptide-1 receptor agonist (recombinant exendin-4, rE-4) in Chinese patients with type 2 diabetes mellitus
. Zang YN, Zhang MJ, Wang YT, Wang C, Wang Q, Zheng QS, Ji LN, Guo W, Fang Y.Int J Clin Pharmacol Ther. 2017 May 17. doi: 10.5414/CP202973. [Epub ahead of print] PMID: 28513427
9:Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by 19F-NMR observation of 4-fluorophenylalanine. Hou Y, Hu W, Li X, Skinner JJ, Liu D, Wüthrich K.J Biomol NMR. 2017 May 15. doi: 10.1007/s10858-017-0107-8. [Epub ahead of print] PMID: 28508109
10:Response by Wiberg et al to Letter Regarding Article, /Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest: A Randomized Controlled Trial/. Wiberg S, Hassager C, Kjaergaard J.Circulation. 2017 May 16;135(20):e1044-e1045. doi: 10.1161/CIRCULATIONAHA.117.027774. No abstract available. PMID: 28507255