glucagon receptor antagonists-3

• CAT Number: I002564
• CAS Number: 202917-17-7
• Molecular Formula: C22H32FNO2
• Molecular Weight: 361.49
• Purity: ≥95%
• Synonyms: 5-fluoro-2-((R)-3-((R)-1-hydroxyethyl)-2,6-diisopropyl-5-propyl-1,4-dihydropyridin-4-yl)phenol
• Target: GCGR
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Glucagon Receptor Antagonist-3 (Cat No.: I002564) is a selective inhibitor targeting the glucagon receptor (GCGR), which plays a key role in glucose metabolism. By blocking GCGR signaling, it effectively reduces hepatic glucose production, offering potential therapeutic benefits for type 2 diabetes and metabolic disorders. This compound shows strong receptor affinity, favorable pharmacokinetics, and minimal off-target activity. Glucagon Receptor Antagonist-3 is valuable for studying glucagon-related pathways and developing treatments aimed at improving glycemic control and insulin sensitivity in diabetic patients.

Reference

[1]. Ladouceur, Gaetan H. et al. Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists. Bioorganic & Medicinal Chemistry Letters (2002), 12(23), 3421-3424.