For research use only. Not for therapeutic Use.
Glucocorticoid receptor agonist-1 Ala-Ala-Mal（Cat No.:I042325）is a synthetic peptide compound designed to activate the glucocorticoid receptor (GR), a key receptor involved in regulating inflammation, immune response, and metabolism. The compound contains an Ala-Ala (alanine-alanine) sequence, which may enhance its binding affinity to the receptor, and Mal (malonyl) as part of its chemical structure. By binding to the GR, it mimics the effects of glucocorticoids, which are commonly used to treat inflammatory and autoimmune diseases. Research is ongoing to assess its therapeutic potential, pharmacokinetics, and efficacy in various conditions, including chronic inflammation.
| Catalog Number | I042325 |
| CAS Number | 2166376-51-6 |
| Synonyms | (2S)-2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-N-[(2S)-1-[3-[[4-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-6-yl]phenyl]methyl]anilino]-1-oxopropan-2-yl]propanamide |
| Molecular Formula | C48H54N4O11 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-N-[(2S)-1-[3-[[4-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-6-yl]phenyl]methyl]anilino]-1-oxopropan-2-yl]propanamide |
| InChI | InChI=1S/C48H54N4O11/c1-26(49-39(57)17-19-52-40(58)14-15-41(52)59)43(60)50-27(2)44(61)51-32-7-5-6-29(21-32)20-28-8-10-30(11-9-28)45-62-38-23-35-34-13-12-31-22-33(54)16-18-46(31,3)42(34)36(55)24-47(35,4)48(38,63-45)37(56)25-53/h5-11,14-16,18,21-22,26-27,34-36,38,42,45,53,55H,12-13,17,19-20,23-25H2,1-4H3,(H,49,57)(H,50,60)(H,51,61)/t26-,27-,34-,35-,36-,38+,42+,45+,46-,47-,48+/m0/s1 |
| InChIKey | STCNTKNIXVQMDF-ZYKKSPNHSA-N |
| SMILES | C[C@@H](C(=O)N[C@@H](C)C(=O)NC1=CC=CC(=C1)CC2=CC=C(C=C2)[C@@H]3O[C@@H]4C[C@H]5[C@@H]6CCC7=CC(=O)C=C[C@@]7([C@H]6[C@H](C[C@@]5([C@@]4(O3)C(=O)CO)C)O)C)NC(=O)CCN8C(=O)C=CC8=O |
