Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal

• CAT Number: I040145
• CAS Number: 2345732-83-2
• Molecular Formula: C46H50N3O15P
• Molecular Weight: 915.87
• Purity: ≥95%
• Synonyms: (4S)-4-[[2-(2,5-dioxopyrrol-1-yl)acetyl]amino]-5-[3-[[4-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-11-hydroxy-9,13-dimethyl-16-oxo-8-(2-phosphonooxyacetyl)-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-6-yl]phenyl]methyl]anilino]-5-oxopentanoic acid
• InChI: InChI=1S/C46H50N3O15P/c1-44-17-16-30(50)20-28(44)10-11-31-32-21-36-46(35(52)24-62-65(59,60)61,45(32,2)22-34(51)41(31)44)64-43(63-36)27-8-6-25(7-9-27)18-26-4-3-5-29(19-26)47-42(58)33(12-15-40(56)57)48-37(53)23-49-38(54)13-14-39(49)55/h3-9,13-14,16-17,19-20,31-34,36,41,43,51H,10-12,15,18,21-24H2,1-2H3,(H,47,58)(H,48,53)(H,56,57)(H2,59,60,61)/t31-,32-,33-,34-,36+,41+,43+,44-,45-,46+/m0/s1
• InChIKey: BACFCSKNRKGXJF-YFTVFXHHSA-N
• SMILES: CC12CC(C3C(C1CC4C2(OC(O4)C5=CC=C(C=C5)CC6=CC(=CC=C6)NC(=O)C(CCC(=O)O)NC(=O)CN7C(=O)C=CC7=O)C(=O)COP(=O)(O)O)CCC8=CC(=O)C=CC38C)O

Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal (Cat No.: I040145) is a synthetic peptide designed to activate the glucocorticoid receptor (GR), a key regulator of inflammation, metabolism, and immune response. The peptide contains a glycine-glutamic acid (Gly-Glu) sequence and is conjugated with malonic acid (Mal) to enhance its pharmacological properties. Upon activation of GR, it can modulate inflammatory pathways, making it potentially useful in treating conditions like autoimmune disorders, allergies, and chronic inflammation. Its specificity allows for targeted effects with minimal side effects.

Reference

[1]. Hobson A D, et al. Anti-cd40 antibody drug conjugates. World Intellectual Property Organization. WO2019106608A1.