Glucocorticoid receptor agonist-4

• CAT Number: I040156
• CAS Number: 2842165-72-2
• Molecular Formula: C36H40FNO7
• Molecular Weight: 617.70
• Purity: ≥95%
• Synonyms: (1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-[3-[(3-aminophenyl)methoxy]-2-fluoro-6-methylphenyl]-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
• InChI: InChI=1S/C36H40FNO7/c1-19-7-10-27(43-18-20-5-4-6-22(38)13-20)32(37)30(19)33-44-29-15-25-24-9-8-21-14-23(40)11-12-34(21,2)31(24)26(41)16-35(25,3)36(29,45-33)28(42)17-39/h4-7,10-14,24-26,29,31,33,39,41H,8-9,15-18,38H2,1-3H3/t24-,25-,26-,29+,31+,33+,34-,35-,36+/m0/s1
• InChIKey: HNGDCWMBBDBZCI-ALOVAHRDSA-N
• SMILES: CC1=C(C(=C(C=C1)OCC2=CC(=CC=C2)N)F)C3OC4CC5C6CCC7=CC(=O)C=CC7(C6C(CC5(C4(O3)C(=O)CO)C)O)C

Glucocorticoid receptor agonist-4 (Cat No.: I040156) is a small-molecule compound designed to selectively activate the glucocorticoid receptor (GR), a key transcription factor involved in regulating inflammatory and immune responses. By binding to GR, this agonist modulates gene expression, potentially reducing inflammation and regulating immune functions. It shows promise in treating inflammatory diseases such as asthma, rheumatoid arthritis, and autoimmune disorders. Research into glucocorticoid receptor agonist-4 is focused on enhancing its therapeutic potential while minimizing side effects commonly associated with traditional glucocorticoid therapies.

Reference

[1]. Grace CHAO, et al. Human tumor necrosis factor alpha antibody glucocorticoid conjugates. Patent WO2023220549A1.