For research use only. Not for therapeutic Use.
Glucocorticoid Receptor (GR) Agonist(CAT: I000972) is a compound that binds to and activates the glucocorticoid receptor, a nuclear receptor involved in regulating gene expression. These agonists mimic the effects of endogenous glucocorticoids, such as cortisol, and are widely used in immunology, inflammation, and metabolic research. GR agonists exert anti-inflammatory and immunosuppressive effects by inhibiting pro-inflammatory cytokine production and promoting the expression of anti-inflammatory proteins. They are valuable tools for studying conditions like autoimmune diseases, asthma, allergies, and metabolic syndromes. Additionally, GR agonists are investigated in preclinical and clinical settings for their therapeutic potential in diseases involving dysregulated immune or stress responses. Examples include dexamethasone, prednisolone, and hydrocortisone.
| Catalog Number | I000972 |
| CAS Number | 1245526-82-2 |
| Synonyms | 4-fluoro-2-[(4R)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol |
| Molecular Formula | C20H20F4N2O2 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 4-fluoro-2-[(4R)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol |
| InChI | InChI=1S/C20H20F4N2O2/c1-18(2,15-8-13(21)3-4-17(15)27)11-19(28,20(22,23)24)9-14-7-12-5-6-25-10-16(12)26-14/h3-8,10,26-28H,9,11H2,1-2H3/t19-/m0/s1 |
| InChIKey | JFUAWXPBHXKZGA-IBGZPJMESA-N |
| SMILES | CC(C)(C[C@@](CC1=CC2=C(N1)C=NC=C2)(C(F)(F)F)O)C3=C(C=CC(=C3)F)O |
