Glutaminase C-IN-1 (968)

• CAT Number: I003099
• CAS Number: 311795-38-7
• Molecular Formula: C₂₇H₂₇BrN₂O
• Molecular Weight: 475.42
• Purity: ≥95%
• Synonyms: 5-[3-bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethyl-benzo[a]phenanthridin-4(1H)-one
• Target: Glutaminase
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChI: InChI=1S/C27H27BrN2O/c1-27(2)14-19-24-18-8-6-5-7-16(18)9-11-21(24)29-26(25(19)23(31)15-27)17-10-12-22(30(3)4)20(28)13-17/h5-13,26,29H,14-15H2,1-4H3
• InChIKey: NVFRRJQWRZFDLM-UHFFFAOYSA-N
• SMILES: CC1(CC2=C(C(NC3=C2C4=CC=CC=C4C=C3)C5=CC(=C(C=C5)N(C)C)Br)C(=O)C1)C

Glutaminase C-IN-1 (968) (CAT: I003099) stands out as an allosteric inhibitor specifically targeting Glutaminase C, an enzyme involved in glutamine metabolism. This inhibitor’s distinctive mechanism of action allows it to selectively inhibit the growth of cancer cells while leaving their normal cellular counterparts unaffected. By targeting the altered metabolism of cancer cells, Glutaminase C-IN-1 (968) offers potential avenues for developing innovative cancer therapies.

Reference

[1]. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.