Glutaminyl Cyclase Inhibitor 1

• CAT Number: I020073
• CAS Number: 2110449-60-8
• Molecular Formula: C21H24FN3O2
• Molecular Weight: 369.43
• Purity: ≥95%
• Synonyms: 2-(3,4-dimethoxyphenyl)-6-fluoro-N-[3-(4-methylimidazol-1-yl)propyl]aniline
• InChI: InChI=1S/C21H24FN3O2/c1-15-13-25(14-24-15)11-5-10-23-21-17(6-4-7-18(21)22)16-8-9-19(26-2)20(12-16)27-3/h4,6-9,12-14,23H,5,10-11H2,1-3H3
• InChIKey: QBJVKQMFLLMSJR-UHFFFAOYSA-N
• SMILES: CC1=CN(C=N1)CCCNC2=C(C=CC=C2F)C3=CC(=C(C=C3)OC)OC

Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with an IC50 of 0.5 μM.
Glutaminyl Cyclase Inhibitor 1 is compound 23[1].

Reference

[1]. Li M, et al. Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer’s Disease. J Med Chem. 2017 Aug 10;60(15):6664-6677.
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