Glutathione arsenoxide

• CAT Number: I006625
• CAS Number: 1271726-51-2
• Molecular Formula: C18H25AsN4O9S
• Molecular Weight: 548.40
• Purity: ≥95%
• Synonyms: Glutathione arsenoxide; GSAO;;N5-((R)-1-((carboxymethyl)amino)-3-((2-((4-(dihydroxyarsanyl)phenyl)amino)-2-oxoethyl)thio)-1-oxopropan-2-yl)-L-glutamine
• Target: Mitochondrial Metabolism
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• InChI: InChI=1S/C18H25AsN4O9S/c20-12(18(29)30)5-6-14(24)23-13(17(28)21-7-16(26)27)8-33-9-15(25)22-11-3-1-10(2-4-11)19(31)32/h1-4,12-13,31-32H,5-9,20H2,(H,21,28)(H,22,25)(H,23,24)(H,26,27)(H,29,30)/t12-,13-/m0/s1
• InChIKey: ADJQAKCDADMLPP-STQMWFEESA-N
• SMILES: O=C(O)CNC([C@H](CSCC(NC1=CC=C([As](O)O)C=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)=O

Glutathione arsenoxide(CAT: I006625) is a metabolite formed through the detoxification of arsenic by the enzyme glutathione S-transferase (GST). This compound results from the conjugation of arsenic with glutathione, a tripeptide that plays a crucial role in cellular detoxification processes. Glutathione arsenoxide is important in studies focused on arsenic metabolism, toxicity, and resistance mechanisms. Understanding its formation and breakdown is key to investigating the cellular defense against arsenic exposure and its implications for human health, particularly in toxicology research aimed at developing strategies to mitigate arsenic poisoning and its associated risks.