Glutathione Disulfide

• CAT Number: R012121
• CAS Number: 27025-41-8
• Molecular Formula: C20H32N6O12S2
• Molecular Weight: 612.63
• Purity: ≥95%
• Synonyms: N,N’-[Dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]diglutamine; GSSG; Glutathione Disulphide; Glutathione Oxidized; Glutathione-S-S-glutathione; Glutathione-SSG; Glutathone Disulfide; Oxidized L-Glutathione; Oxidized Glutathione; Oxiglutatione
• Target: NF-κB
• Storage: -20°C
• IUPAC Name: (2S)-2-amino-5-[[(2R)-3-[[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]disulfanyl]-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• InChI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/t9-,10-,11-,12-/m0/s1
• InChIKey: YPZRWBKMTBYPTK-BJDJZHNGSA-N
• SMILES: C(CC(=O)NC(CSSCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N)C(=O)NCC(=O)O)C(C(=O)O)N

Glutathione disulfide (GSSG)(CAT: R012121) is the oxidized form of glutathione (GSH), an essential antioxidant in cells. GSH protects cells from oxidative damage by neutralizing harmful reactive oxygen species (ROS). During this process, two GSH molecules form a disulfide bond, creating GSSG. The enzyme glutathione reductase converts GSSG back to GSH, ensuring a balance between the reduced and oxidized forms. This redox balance is vital for cellular health, detoxification, and regulating oxidative stress. Disruption in the GSH/GSSG ratio is associated with various diseases, including cancer and neurodegenerative disorders, making it a key focus in biomedical and clinical research.