For research use only. Not for therapeutic Use.
GLX351322 (Cat No.:I020055) is an inhibitor of NADPH oxidase 4 (NOX4). GLX351322 inhibits tetracycline-induced hydrogen peroxide production in NOX4-overexpressing cells with an IC50 of 5 μM. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I020055 |
| CAS Number | 835598-94-2 |
| Molecular Formula | C₂₁H₂₅N₃O₅S |
| Purity | ≥95% |
| Target | NADPH Oxidase |
| IUPAC Name | ethyl 2-[[2-[4-(furan-2-carbonyl)piperazin-1-yl]acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate |
| InChI | InChI=1S/C21H25N3O5S/c1-2-28-21(27)18-14-5-3-7-16(14)30-19(18)22-17(25)13-23-8-10-24(11-9-23)20(26)15-6-4-12-29-15/h4,6,12H,2-3,5,7-11,13H2,1H3,(H,22,25) |
| InChIKey | KEVHLTCEMHIJTQ-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C(SC2=C1CCC2)NC(=O)CN3CCN(CC3)C(=O)C4=CC=CO4 |
| Reference | [1]. Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49(11):1308-18. |
