For research use only. Not for therapeutic Use.
GLX481304(CAT: I040904) is a selective inhibitor of NADPH oxidase isoforms Nox-2 and Nox-4, with IC50 values of 1.25 μM. Nox enzymes are major contributors to reactive oxygen species (ROS) production, which is implicated in oxidative stress and tissue damage, particularly in cardiovascular diseases. GLX481304 effectively suppresses ROS production in isolated mouse cardiomyocytes, leading to improved cardiomyocyte contractility. This makes GLX481304 a promising compound for research on ischemic injury to the heart, offering potential for therapeutic interventions aimed at reducing oxidative stress and enhancing heart function after ischemic events. This compound is highly relevant for Cardiovascular Disease Research.
| CAS Number | 701224-63-7 |
| Synonyms | 2-N-(3,4-dimethylphenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-1,3,5-triazine-2,4-diamine |
| Molecular Formula | C23H29N7O |
| Purity | ≥95% |
| IUPAC Name | 2-N-(3,4-dimethylphenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-1,3,5-triazine-2,4-diamine |
| InChI | InChI=1S/C23H29N7O/c1-16-7-8-18(13-17(16)2)25-23-27-21(26-22(24)28-23)15-29-9-11-30(12-10-29)19-5-4-6-20(14-19)31-3/h4-8,13-14H,9-12,15H2,1-3H3,(H3,24,25,26,27,28) |
| InChIKey | STKSULQULJWEMU-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC2=NC(=NC(=N2)N)CN3CCN(CC3)C4=CC(=CC=C4)OC)C |
