For research use only. Not for therapeutic Use.
Gly-7-MAD-MDCPT (compound 4b) is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin (HY-16560) compound, it shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM[1].
Gly-7-MAD-MDCPT (0.1-1000 nM) shows cytotoxic potency to 786-0, BxPC3, HL-60 and SK-MEL-5 with IC50 values of 100-1000 nM[1].
Gly-7-MAD-MDCPT (0.1-1000 nM) shows cytotoxic potency to L540cy, MM.1R, M0LM13, Ramos, SK-MEL-5, SU-DHL-4 and U266 with IC50 values of 10-100 nM[1].
| Catalog Number | I042663 |
| CAS Number | 2378427-68-8 |
| Synonyms | 2-amino-N-[[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]methyl]acetamide |
| Molecular Formula | C24H22N4O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H22N4O7/c1-2-24(32)15-4-17-21-13(8-28(17)22(30)14(15)9-33-23(24)31)12(7-26-20(29)6-25)11-3-18-19(35-10-34-18)5-16(11)27-21/h3-5,32H,2,6-10,25H2,1H3,(H,26,29)/t24-/m0/s1 |
| InChIKey | LSGAIOTZJXLIGC-DEOSSOPVSA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC6=C(C=C5N=C4C3=C2)OCO6)CNC(=O)CN)O |
| Reference | [1]. Jeffrey Scott, et al. Preparation of camptothecin peptide conjugates as antitumor agents. WO2019195665. 2019 10-10. |
