For research use only. Not for therapeutic Use.
Gly-Arg-Gly-Asp-Ser (Cat.No:I020629) is a peptide sequence commonly known as GRGDS. It is recognized as a cell-adhesive motif and plays a significant role in cell adhesion and signaling processes. GRGDS has been extensively studied for its potential applications in tissue engineering, drug delivery systems, and biomedical research related to cell-matrix interactions.
| Catalog Number | I020629 |
| CAS Number | 96426-21-0 |
| Molecular Formula | C₁₇H₃₀N₈O₉ |
| Purity | ≥95% |
| Target | Integrin |
| IUPAC Name | (3S)-3-[[2-[[(2S)-2-[(2-aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid |
| InChI | InChI=1S/C17H30N8O9/c18-5-11(27)23-8(2-1-3-21-17(19)20)14(31)22-6-12(28)24-9(4-13(29)30)15(32)25-10(7-26)16(33)34/h8-10,26H,1-7,18H2,(H,22,31)(H,23,27)(H,24,28)(H,25,32)(H,29,30)(H,33,34)(H4,19,20,21)/t8-,9-,10-/m0/s1 |
| InChIKey | RGNVSYKVCGAEHK-GUBZILKMSA-N |
| SMILES | C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)O)NC(=O)CN)CN=C(N)N |
| Reference | [1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997.<br>[2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9. |
