Gly-Gly-Gly-PEG4-azide

• CAT Number: I045187
• Molecular Formula: C16H31N7O7
• Molecular Weight: 433.46
• Purity: ≥95%
• Synonyms: 2-amino-N-[2-[[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]-2-oxoethyl]acetamide
• InChI: InChI=1S/C16H31N7O7/c17-11-14(24)20-13-16(26)21-12-15(25)19-1-3-27-5-7-29-9-10-30-8-6-28-4-2-22-23-18/h1-13,17H2,(H,19,25)(H,20,24)(H,21,26)
• InChIKey: XKWKEPSEKGSYSV-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCN=[N+]=[N-])NC(=O)CNC(=O)CNC(=O)CN

Gly-Gly-Gly-PEG4-azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
 [Content Brief]