For research use only. Not for therapeutic Use.
Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Enzyme activity can be quantified by colorimetric detection of free <em>p</em>-nitroanilide at 405 nm. DPP IV inactivates the two peptides responsible for a majority of nutrient-stimulated insulin secretion: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1). This substrate can be used to screen for DPP IV inhibitors, which have emerged as a new class of experimental antidiabetic agents.
| Catalog Number | M001684 |
| CAS Number | 103213-34-9 |
| Synonyms | Gly-Pro p-nitroanilide |
| Molecular Formula | C13H16N4O4 • HCl |
| Purity | ≥95% |
| Storage | -20°C |
| InChIKey | VBBFIBMVFSUUBP-MERQFXBCSA-N |
