For research use only. Not for therapeutic Use.
Glycerol phenylbutyrate (Cat No.:I006985) is a prodrug of phenylbutyrate, used primarily in the treatment of urea cycle disorders (UCDs), a group of rare genetic conditions that impair the body’s ability to remove ammonia. GPB is converted into phenylbutyrate in the body, which then helps remove excess ammonia by promoting its conversion to less toxic compounds that can be excreted in the urine. It has been shown to reduce ammonia levels, thus preventing neurotoxic effects. GPB is also being studied for potential applications in managing other metabolic or neurodegenerative diseases due to its ability to modulate cellular metabolism.
| Catalog Number | I006985 |
| CAS Number | 611168-24-2 |
| Synonyms | HPN-100; HPN 100; HPN100; Glycerol phenylbutyrate, trade name: Ravicti.;propane-1,2,3-triyl tris(4-phenylbutanoate) |
| Molecular Formula | C33H38O6 |
| Purity | ≥95% |
| Target | Sigma Receptor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 2,3-bis(4-phenylbutanoyloxy)propyl 4-phenylbutanoate |
| InChI | InChI=1S/C33H38O6/c34-31(22-10-19-27-13-4-1-5-14-27)37-25-30(39-33(36)24-12-21-29-17-8-3-9-18-29)26-38-32(35)23-11-20-28-15-6-2-7-16-28/h1-9,13-18,30H,10-12,19-26H2 |
| InChIKey | ZSDBFLMJVAGKOU-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CCCC(=O)OCC(COC(=O)CCCC2=CC=CC=C2)OC(=O)CCCC3=CC=CC=C3 |
