For research use only. Not for therapeutic Use.
Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration[1][2].
| Catalog Number | I043247 |
| CAS Number | 7412-78-4 |
| Synonyms | (2S)-2-[(2-aminoacetyl)amino]pentanedioic acid |
| Molecular Formula | C7H12N2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C7H12N2O5/c8-3-5(10)9-4(7(13)14)1-2-6(11)12/h4H,1-3,8H2,(H,9,10)(H,11,12)(H,13,14)/t4-/m0/s1 |
| InChIKey | IEFJWDNGDZAYNZ-BYPYZUCNSA-N |
| SMILES | C(CC(=O)O)C(C(=O)O)NC(=O)CN |
| Reference | [1]. Koelle GB, et al. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Proc [2]. Yourick JJ, et al. Regeneration of acetylcholinesterase in clonal neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition: effect of glycyl-L-glutamine. Cell Biol Toxicol. 1991 Jul;7(3):229-37. |
