Glycyrrhetic Acid 3-O-β-D-Glucuronide

• CAT Number: R048749
• CAS Number: 34096-83-8
• Molecular Formula: C36H54O10
• Molecular Weight: 646.818
• Purity: ≥95%
• Synonyms: (3β,20β)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl β-D-Glucopyranosiduronic Acid; ?3β-(β-D-Glucopyranuronosyloxy)-11-oxoolean-12-en-30-oic Acid; GM 3290; Glycyrrhetic Acid 3-O-Glucuronide; Starrhizin
• Target: Disease Research Fields
• Storage: -20°C
• IUPAC Name: (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
• InChI: InChI=1S/C36H54O10/c1-31(2)21-8-11-36(7)27(34(21,5)10-9-22(31)45-29-25(40)23(38)24(39)26(46-29)28(41)42)20(37)16-18-19-17-33(4,30(43)44)13-12-32(19,3)14-15-35(18,36)6/h16,19,21-27,29,38-40H,8-15,17H2,1-7H3,(H,41,42)(H,43,44)/t19-,21-,22-,23-,24-,25+,26-,27+,29+,32+,33-,34-,35+,36+/m0/s1
• InChIKey: HLDYLAJAWSKPFZ-QDPIGISRSA-N
• SMILES: CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)O)C)C(=O)C=C5C3(CCC6(C5CC(CC6)(C)C(=O)O)C)C)C)C

Glycyrrhetic acid 3-O-β-D-glucuronide is a metabolite of glycyrrhetic acid, a triterpenoid compound found in licorice root (Glycyrrhiza glabra). This glucuronide conjugate enhances the water solubility and excretion of glycyrrhetic acid. It is studied for its potential pharmacological effects, such as anti-inflammatory and antioxidant properties, which may contribute to licorice’s traditional medicinal uses. Research focuses on understanding its bioactivity, metabolism, and therapeutic potential in various health conditions, including liver diseases and inflammatory disorders.