Glyoxalase I inhibitor 5

• CAT Number: I043657
• CAS Number: 2455508-17-3
• Molecular Formula: C16H14N4O3S
• Molecular Weight: 342.37
• Purity: ≥95%
• Synonyms: 5-[(8-hydroxyquinolin-5-yl)diazenyl]-2-methylbenzenesulfonamide
• InChI: InChI=1S/C16H14N4O3S/c1-10-4-5-11(9-15(10)24(17,22)23)19-20-13-6-7-14(21)16-12(13)3-2-8-18-16/h2-9,21H,1H3,(H2,17,22,23)
• InChIKey: HZHXXZUPMORJKH-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)N=NC2=C3C=CC=NC3=C(C=C2)O)S(=O)(=O)N

Glyoxalase I inhibitor 5 (Compound 9h) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.28 μM. Glyoxalase I inhibitor 5 can be used as anticancer agent[1].

Reference

[1]. Al-Oudat BA, et al. Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents. Bioorg Med Chem. 2020 Aug 15;28(16):115608.
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