Glyoxalase I inhibitor

• CAT Number: I002693
• CAS Number: 221174-33-0
• Molecular Formula: C21H30BrClN4O8S
• Molecular Weight: 613.91
• Purity: ≥95%
• Synonyms: ethyl (2S)-2-amino-5-[[(2R)-3-[(4-bromophenyl)-hydroxycarbamoyl]sulfanyl-1-[(2-ethoxy-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate hydrochloride
• Target: Glyoxalase (GLO)
• Solubility: DMSO: ≥ 37 mg/mL
• Storage: Store at -20°C
• IUPAC Name: ethyl (2S)-2-amino-5-[[(2R)-3-[(4-bromophenyl)-hydroxycarbamoyl]sulfanyl-1-[(2-ethoxy-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate;hydrochloride
• InChI: InChI=1S/C21H29BrN4O8S.ClH/c1-3-33-18(28)11-24-19(29)16(25-17(27)10-9-15(23)20(30)34-4-2)12-35-21(31)26(32)14-7-5-13(22)6-8-14;/h5-8,15-16,32H,3-4,9-12,23H2,1-2H3,(H,24,29)(H,25,27);1H/t15-,16-;/m0./s1
• InChIKey: HFQRZRCYYQCUIG-MOGJOVFKSA-N
• SMILES: CCOC(=O)CNC(=O)[C@H](CSC(=O)N(C1=CC=C(C=C1)Br)O)NC(=O)CC[C@@H](C(=O)OCC)N.Cl

Glyoxalase I inhibitor(CAT: I002693) is a compound that specifically targets glyoxalase I, a key enzyme in the glyoxalase system responsible for detoxifying methylglyoxal, a reactive dicarbonyl compound. By inhibiting this enzyme, it disrupts cellular detoxification processes, making it a valuable tool for studying metabolic pathways and oxidative stress. Glyoxalase I inhibitors are particularly relevant in cancer research, as this enzyme is often upregulated in tumors to counteract high metabolic stress. These inhibitors are also studied for their potential in addressing diabetic complications and neurodegenerative diseases. With high specificity, they serve as essential tools for exploring glyoxalase I’s role in health and disease and for advancing therapeutic development.