GlyRS-IN-1

• CAT Number: I013002
• CAS Number: 112921-11-6
• Molecular Formula: C₁₂H₁₇N₇O₇S
• Molecular Weight: 403.37
• Purity: ≥95%
• Target: Anti-infection
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-(2-aminoacetyl)sulfamate
• InChI: InChI=1S/C12H17N7O7S/c13-1-6(20)18-27(23,24)25-2-5-8(21)9(22)12(26-5)19-4-17-7-10(14)15-3-16-11(7)19/h3-5,8-9,12,21-22H,1-2,13H2,(H,18,20)(H2,14,15,16)/t5-,8-,9-,12-/m1/s1
• InChIKey: AMWPZASLDLLQFT-JJNLEZRASA-N
• SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COS(=O)(=O)NC(=O)CN)O)O)N

GlyRS-IN-1（Cat No.:I013002）is a potent and selective inhibitor of glycyl-tRNA synthetase (GlyRS), an enzyme involved in protein synthesis by catalyzing the attachment of glycine to its corresponding tRNA. By inhibiting GlyRS, GlyRS-IN-1 disrupts protein synthesis and has potential therapeutic applications in diseases where GlyRS activity is dysregulated. It is being investigated for its role in neurological disorders and certain cancers due to its impact on cellular translation processes. GlyRS-IN-1 is a valuable tool for researchers exploring the role of aminoacyl-tRNA synthetases in disease mechanisms.

Reference

[1]. Xiang-Lei Yang, et al. INHIBITION OF NEDDYLATION USING GLYCYL-tRNA SYNTHETASE INHIBITORS. WO 2017066459 A1.