GMC 1-109

• CAT Number: I047517
• CAS Number: 183140-96-7
• Molecular Formula: C19H19F3N4O3S
• Molecular Weight: 440.44
• Purity: ≥95%
• IUPAC Name: [6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-3-yl] trifluoromethanesulfonate
• InChI: InChI=1S/C19H19F3N4O3S/c1-25-8-10-26(11-9-25)18-14-4-2-3-5-15(14)23-16-7-6-13(12-17(16)24-18)29-30(27,28)19(20,21)22/h2-7,12,23H,8-11H2,1H3
• SMILES: CN1CCN(CC1)C2=NC3=C(C=CC(=C3)OS(=O)(=O)C(F)(F)F)NC4=CC=CC=C42

Analogue of clozapine (Axon 1146); devoid of DA, 5-HT2, H1 and α1 affinities, but with high M1 affinity (IC50 value of 35 nM).
KEYWORDS: GMC 1-109 | supplier | Clozapine analog | GMC1-109 | GMC1109 | CAS [183140-96-7] | Axon Medchem | Axon 1289 | Acetylcholine | CHRM1 | Antagonist | Receptors | Muscarinic

Reference

Y Liao et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53.

 

Y Liao et al. New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J Med Chem. 1999 Jun 17;42(12):2235-44.