GMC 1-116

• CAT Number: I047506
• CAS Number: 63687-94-5
• Molecular Formula: C18H20N4O
• Molecular Weight: 308.38
• Purity: ≥95%
• IUPAC Name: 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-3-ol
• InChI: InChI=1S/C18H20N4O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-15(14)19-16-7-6-13(23)12-17(16)20-18/h2-7,12,19,23H,8-11H2,1H3
• SMILES: CN1CCN(CC1)C2=NC3=C(C=CC(=C3)O)NC4=CC=CC=C42

Analogue and metabolite of clozapine (Axon 1146); devoid of DA and α1 affinities, with weak 5-HT2 affinities but high M1 affinity (IC50=27 nM).
Another analogue and metabolite of cloazapine, with 2-Hydroxy moiety, GMC1-165 (Axon 1152), is also available.
KEYWORDS: GMC 1-116 | supplier | Clozapine analogue | GMC1-116 | CAS [63687-94-5] | Serotonin; Dopamine | D (Non Selective) | 5-HT (Non Selective) | Agonist | Receptors

Reference

Liao, Y. et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of Clozapine: Identification of a novel atypical neuroleptic. J. Med. Chem. 1997, 40, 4146-4153.

 

Y. Liao et al. New sulfonyloxy piperazinyldibenzazapines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J. Med. Chem. 1999,42, 2235-2244.