For research use only. Not for therapeutic Use.
Analogue of clozapine (Axon 1146); devoid of affinity for the DA D1 receptor, but with affinities at 5-HT2A/2C, hM1 and DA D2 receptors.
KEYWORDS: GMC 1-161 | supplier | Clozapine analogue | GMC1-161 | GMC1161 | CAS [95316-97-5] | Serotonin | 5-HT2A | 5-HT2C | CHRM1 | D2 | Agonist | Receptors
| Catalog Number | I047634 |
| CAS Number | 95316-97-5 |
| Molecular Formula | C19H22N4O |
| Purity | ≥95% |
| IUPAC Name | 8-methoxy-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
| InChI | InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-13-14(24-2)7-8-16(15)20-17-5-3-4-6-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3 |
| SMILES | CN1CCN(CC1)C2=NC3=CC=CC=C3NC4=C2C=C(C=C4)OC |
| Reference | Y Liao et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53.
Y Liao et al. New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J Med Chem. 1999 Jun 17;42(12):2235-44. |
