GMC 1-165

• CAT Number: M098974
• CAS Number: 156632-07-4
• Molecular Formula: C18H20N4O
• Molecular Weight: 308.38
• Purity: ≥95%
• IUPAC Name: 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-8-ol
• InChI: InChI=1S/C18H20N4O/c1-21-8-10-22(11-9-21)18-14-12-13(23)6-7-15(14)19-16-4-2-3-5-17(16)20-18/h2-7,12,19,23H,8-11H2,1H3
• SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3NC4=C2C=C(C=C4)O

Analogue of clozapine (Axon 1146); devoid of DA affinities but with affinities at 5-HT2A/2C and hM1 receptors.
Another analogue and metabolite of cloazapine, with 8-hydroxy moiety, GMC1-116 (Axon 1151), is also available.
KEYWORDS: GMC 1-165 | supplier | Clozapine analogue | GMC1-165 | GMC1165 | CAS [156632-07-4] | Serotonin | 5-HT2A | 5-HT2C | CHRM1 | Agonist | Receptors

Reference

Liao, Y. et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of Clozapine: Identification of a novel atypical neuroleptic. J. Med. Chem. 1997, 40, 4146-4153.

 

Y. Liao et al. New sulfonyloxy piperazinyldibenzazapines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J. Med. Chem. 1999,42, 2235-2244.