For research use only. Not for therapeutic Use.
GMQ is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research[1].
GMQ (1 mM) generates a sustained inward current at pH 7.4 in CHO cells[1].
GMQ blocks ASIC pore at high concentrations with IC50 values of 3.24, 1.52 and 6.74 mM for ASIC1a, ASIC1b and ASIC3, respectively[1].
| Catalog Number | I011079 |
| CAS Number | 5361-15-9 |
| Synonyms | 2-(4-methylquinazolin-2-yl)guanidine;hydrochloride |
| Molecular Formula | C10H12ClN5 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H11N5.ClH/c1-6-7-4-2-3-5-8(7)14-10(13-6)15-9(11)12;/h2-5H,1H3,(H4,11,12,13,14,15);1H |
| InChIKey | VNPZWQRWOHFAPD-UHFFFAOYSA-N |
| SMILES | CC1=NC(=NC2=CC=CC=C12)N=C(N)N.Cl |
| Reference | [1]. Alijevic O, Kellenberger S. Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J Biol Chem. 2012 Oct 19;287(43):36059-70. |
