For research use only. Not for therapeutic Use.
GN25 is a specific p53-Snail binding inhibitor with antitumor effects[1].
GN25 (10 and 20 μM; 24 h) inhibits cell viability of K-Ras-mutated MEF cells[1].
GN25 (5 μM; 4 h) activates p53 in a K-Ras-dependent manner[1].
GN25 (1-10 μM; 1-6 h) induces p53 and p21 in a dose- and time- dependent manner in K-Ras-mutated A549 and HCT116 cell lines[1].
GN25 activates wild-type p53 in p53WT/MT cells[1].
GN25 (0.25 μM) recovers the masking effect of p53 on CK1/GSK3b-mediated Snail phosphorylation[1].
GN25 (10 and 20 mg/kg; i.p. once a week for 10 weeks) blocks the tumor progression and induces tumor regression in mice[1].
| Catalog Number | M013899 |
| CAS Number | 1227401-27-5 |
| Synonyms | 3-(5,8-dimethoxy-1,4-dioxonaphthalen-2-yl)sulfanylpropanoic acid |
| Molecular Formula | C15H14O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C15H14O6S/c1-20-9-3-4-10(21-2)14-13(9)8(16)7-11(15(14)19)22-6-5-12(17)18/h3-4,7H,5-6H2,1-2H3,(H,17,18) |
| InChIKey | DIIRLGMLDOPLPV-UHFFFAOYSA-N |
| SMILES | COC1=C2C(=O)C=C(C(=O)C2=C(C=C1)OC)SCCC(=O)O |
| Reference | [1]. Lee SH, Shen GN, Jung YS, Lee SJ, Chung JY, Kim HS, Xu Y, Choi Y, Lee JW, Ha NC, Song GY, Park BJ. Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells. Oncogene. 2010 Aug 12;29(32):4576-87. |
