For research use only. Not for therapeutic Use.
GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].
| Catalog Number | I018141 |
| CAS Number | 1241902-40-8 |
| Synonyms | (2S)-3-methyl-2-[[4-(4-propylcyclohexyl)benzoyl]amino]butanoic acid |
| Molecular Formula | C21H31NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H31NO3/c1-4-5-15-6-8-16(9-7-15)17-10-12-18(13-11-17)20(23)22-19(14(2)3)21(24)25/h10-16,19H,4-9H2,1-3H3,(H,22,23)(H,24,25)/t15?,16?,19-/m0/s1 |
| InChIKey | SKMKUWKJBZSEJH-RJYAGPCLSA-N |
| SMILES | CCCC1CCC(CC1)C2=CC=C(C=C2)C(=O)NC(C(C)C)C(=O)O |
| Reference | [1]. Chernov-Rogan T, et al. Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. |
