For research use only. Not for therapeutic Use.
GNE-140 racemate（Cat No.:I020691）is a small-molecule inhibitor of lactate dehydrogenase A (LDHA), an enzyme critical in cancer metabolism for converting pyruvate to lactate under anaerobic conditions. By inhibiting LDHA, GNE-140 disrupts the glycolytic pathway, reducing lactate production and impairing energy metabolism in cancer cells, particularly those reliant on aerobic glycolysis, or the Warburg effect. This compound is valuable in cancer research, as it helps explore metabolic vulnerabilities in tumors and holds potential for targeting cancers with high glycolytic activity. GNE-140 is studied as a promising therapeutic in oncology.
| Catalog Number | I020691 |
| CAS Number | 1802977-61-2 |
| Molecular Formula | C₂₅H₂₃ClN₂O₃S₂ |
| Purity | ≥95% |
| Target | Lactate Dehydrogenase |
| Storage | 2-8°C |
| IUPAC Name | 3-(2-chlorophenyl)sulfanyl-6-(4-morpholin-4-ylphenyl)-6-thiophen-3-ylpiperidine-2,4-dione |
| InChI | InChI=1S/C25H23ClN2O3S2/c26-20-3-1-2-4-22(20)33-23-21(29)15-25(27-24(23)30,18-9-14-32-16-18)17-5-7-19(8-6-17)28-10-12-31-13-11-28/h1-9,14,16,23H,10-13,15H2,(H,27,30) |
| InChIKey | GLDDJXYFHWRGPI-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC=C(C=C2)C3(CC(=O)C(C(=O)N3)SC4=CC=CC=C4Cl)C5=CSC=C5 |
| Reference | [1]. Ždralević M, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293(41):15947-15961.<br>[2]. Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901. |
