GNE-235

• CAT Number: I040303
• Molecular Formula: C13H16N4O
• Molecular Weight: 244.29
• Purity: ≥95%
• Synonyms: 6-(furan-2-yl)-4-[(2S)-2-methylpyrrolidin-1-yl]pyridazin-3-amine
• InChI: InChI=1S/C13H16N4O/c1-9-4-2-6-17(9)11-8-10(15-16-13(11)14)12-5-3-7-18-12/h3,5,7-9H,2,4,6H2,1H3,(H2,14,16)/t9-/m0/s1
• InChIKey: HDGYSKKTWNREMX-VIFPVBQESA-N
• SMILES: CC1CCCN1C2=CC(=NN=C2N)C3=CC=CO3

GNE-235 is a compound selective for the second bromodomain of PBRM1, with a KD of 0.28 ± 0.02 μM. GNE-235 can be used for evaluation of the cellular function of PBRM1[1].

Reference

[1]. Cochran AG, et al. GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1. J Med Chem. 2023 Sep 28;66(18):13116-13134.
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