For research use only. Not for therapeutic Use.
GNE-6776 is a selective and orally bioavailable USP7 inhibitor[1].
GNE-6776 significantly inhibits USP7 at 15 μM. GNE-6776 is a highly selective USP7 inhibitor against both recombinant and endogenous cellular deubiquitinases[1].
GNE-6776 (100 or 200 mg/kg; oral gavage on a once or twice daily schedule; for 10 days) inhibits EOL-1 xenograft growth in mice[1].
| Catalog Number | I020268 |
| CAS Number | 2009273-71-4 |
| Synonyms | 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)pyridin-3-yl]-N-methylpyridine-2-carboxamide |
| Molecular Formula | C20H20N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20N4O2/c1-3-15-16(13-6-9-17(23-10-13)20(26)22-2)11-24-19(21)18(15)12-4-7-14(25)8-5-12/h4-11,25H,3H2,1-2H3,(H2,21,24)(H,22,26) |
| InChIKey | UCYSSYGGXOFJKK-UHFFFAOYSA-N |
| SMILES | CCC1=C(C(=NC=C1C2=CN=C(C=C2)C(=O)NC)N)C3=CC=C(C=C3)O |
| Reference | [1]. Lorna Kategaya , et al. USP7 Small-Molecule Inhibitors Interfere With Ubiquitin Binding. Nature. 2017 Oct 26;550(7677):534-538. |
