For research use only. Not for therapeutic Use.
GNE-7883(CAT: I040697) is a selective and potent allosteric inhibitor of the TEAD transcription factors, which play a crucial role in the Hippo signaling pathway—a key regulator of cell proliferation, apoptosis, and organ size. By disrupting TEAD auto-palmitoylation, GNE-7883 effectively inhibits TEAD-driven gene expression, making it a promising tool for cancer and regenerative medicine research. It is especially valuable in studies targeting YAP/TAZ-TEAD interactions in solid tumors. GNE-7883 demonstrates strong in vitro activity and favorable pharmacokinetic properties in preclinical models. For researchers investigating Hippo pathway modulation, GNE-7883 offers a powerful approach.
| CAS Number | 2648450-42-2 |
| Synonyms | 5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)-1H-pyrazolo[1,5-a]pyrimidin-7-one |
| Molecular Formula | C28H29FN6O2 |
| Purity | ≥95% |
| IUPAC Name | 5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)-1H-pyrazolo[1,5-a]pyrimidin-7-one |
| InChI | InChI=1S/C28H29FN6O2/c1-17-25(31-12-11-30-17)26-24(28(37)34-15-18(14-29)16-34)27-32-22(13-23(36)35(27)33-26)21-9-7-20(8-10-21)19-5-3-2-4-6-19/h7-13,18-19,33H,2-6,14-16H2,1H3 |
| InChIKey | OMGKSFJZXSXHCA-UHFFFAOYSA-N |
| SMILES | CC1=NC=CN=C1C2=C(C3=NC(=CC(=O)N3N2)C4=CC=C(C=C4)C5CCCCC5)C(=O)N6CC(C6)CF |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
