GNE-7915

• CAT Number: I001355
• CAS Number: 1351761-44-8
• Molecular Formula: C₁₉H₂₁F₄N₅O₃
• Molecular Weight: 443.4
• Purity: ≥95%
• Synonyms: (4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone
• Target: LRRK2
• Solubility: DMSO: ≤ 14.33 mg/mL
• Storage: Store at -20°C
• IC50: 9 nM (cellular assay)
• IUPAC Name: [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone
• InChI: 1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
• InChIKey: XCFLWTZSJYBCPF-UHFFFAOYSA-N
• SMILES: CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC

GNE-7915 (Cat.No:I001355) is a small molecule compound under investigation for its potential therapeutic applications. It is an inhibitor of the enzyme sialic acid synthase (SAS), which is involved in cellular metabolism. GNE-7915 has shown promise in preclinical studies for its potential in treating certain types of cancer and autoimmune disorders. 

Reference

[1]. Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33.