For research use only. Not for therapeutic Use.
Gnetol (CAT: I017399) is a phenolic compound derived from the root of Gnetum ula Brongn, a plant species. It has been found to possess several pharmacological activities. Gnetol exhibits potent inhibitory activity against cyclooxygenase-1 (COX-1) enzyme, with an IC50 value of 0.78 μM. COX-1 is involved in the synthesis of prostaglandins and plays a role in inflammatory processes. Additionally, Gnetol has shown inhibitory effects on histone deacetylases (HDACs), enzymes that regulate gene expression by modifying chromatin structure. The inhibition of HDACs can impact cellular processes such as cell proliferation, differentiation, and apoptosis.
| Catalog Number | I017399 |
| CAS Number | 86361-55-9 |
| Molecular Formula | C₁₄H₁₂O₄ |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Reference | [1]. Remsberg CM, et al. Preclinical Pharmacokinetics and Pharmacodynamics and Content Analysis of Gnetol in Foodstuffs. Phytother Res. 2015 Aug;29(8):1168-79.<br>[2]. Ohguchi K, et al. Gnetol as a potent tyrosinase inhibitor from genus Gnetum. Biosci Biotechnol Biochem. 2003 Mar;67(3):663-5.<br>[3]. Jinadatta P, et al. In silico, in vitro: antioxidant and antihepatotoxic activity of gnetol from Gnetum ula Brongn. Bioimpacts. 2019;9(4):239-249. |
