GNI-50

• CAT Number: I047712
• CAS Number: 1363154-45-3
• Molecular Formula: C19H22N4O4S
• Molecular Weight: 402.47
• Purity: ≥95%
• IUPAC Name: 4-O-[1-(4-acetyloxy-2,3,5-trimethylphenoxy)-3-(propan-2-ylamino)propan-2-yl] 1-O-ethyl but-2-enedioate;4-O-[1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-yl] 1-O-ethyl but-2-enedioate
• InChI: InChI=1S/C24H35NO6.2C23H33NO7/c1-4-29-23(26)11-12-24(27)31-22(15-25-18(2)3)17-30-21-9-7-19(8-10-21)13-14-28-16-20-5-6-20;2*1-8-28-21(26)9-10-22(27)31-19(12-24-14(2)3)13-29-20-11-15(4)23(30-18(7)25)17(6)16(20)5/h7-12,18,20,22,25H,4-6,13-17H2,1-3H3;2*9-11,14,19,24H,8,12-13H2,1-7H3
• SMILES: CCOC(=O)C=CC(=O)OC(CNC(C)C)COC1=CC=C(C=C1)CCOCC2CC2.CCOC(=O)C=CC(=O)OC(CNC(C)C)COC1=C(C(=C(C(=C1)C)OC(=O)C)C)C.CCOC(=O)C=CC(=O)OC(CNC(C)C)COC1=C(C(=C(C(=C1)C)OC(=O)C)C)C

GNI-50 is an orally active NAMPT inhibitor which exhibited excellent biochemical and cellular (A2780) potency with IC50 values of 0.007 μM and 0.032 μM, respectively. GNI-50 also showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model. KEYWORDS: GNI-50 | Supplier | NAMPT inhibitor | SBI796768 | GNI50 | GNI 50 | SBI 796768 | SBI796768 | CAS [1363154-45-3] | Nicotinamide D-ribonucleotide | NAMPT | Inhibitor | Enzymes | Nicotinamide phosphoribosyltransferase | Ovarian tumor

Reference

X Zheng et al. Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. J Med Chem. 2013 Jun 27;56(12):4921-37.