GOAT-IN-1

• CAT Number: I019683
• CAS Number: 1452473-54-9
• Molecular Formula: C18H13ClF3NO3S
• Molecular Weight: 415.81
• Purity: ≥95%
• Synonyms: 2-[4-chloro-6-[[2-methyl-6-(trifluoromethyl)pyridin-3-yl]methoxy]-1-benzothiophen-3-yl]acetic acid
• InChI: InChI=1S/C18H13ClF3NO3S/c1-9-10(2-3-15(23-9)18(20,21)22)7-26-12-5-13(19)17-11(4-16(24)25)8-27-14(17)6-12/h2-3,5-6,8H,4,7H2,1H3,(H,24,25)
• InChIKey: IXAAPJMGWLXOIL-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC(=N1)C(F)(F)F)COC2=CC3=C(C(=C2)Cl)C(=CS3)CC(=O)O

GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.
The inhibitory activity of GOAT-IN-1 (Example 16) for human GOAT is 101% with the concentration of 10 μM[1].

Reference

[1]. WO 2013125732.