For research use only. Not for therapeutic Use.
Goserelin Acetate（Cat No.:I001765）is a synthetic luteinizing hormone-releasing hormone (LHRH) agonist used in hormone therapy for prostate and breast cancers, as well as endometriosis. By stimulating the pituitary gland initially and then desensitizing it, Goserelin Acetate reduces the production of testosterone and estrogen, which are hormones that fuel certain cancers. This action helps slow the growth of hormone-dependent tumors. It is administered as a long-acting implant, providing sustained hormone suppression. Goserelin Acetate is an effective treatment for managing advanced prostate cancer and hormone-sensitive breast cancer.
| Catalog Number | I001765 |
| CAS Number | 145781-92-6 |
| Molecular Formula | C61H88N18O16 |
| Purity | ≥95% |
| Target | GnRH agonist |
| Solubility | DMSO: ≥ 35 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| InChI | InChI=1S/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1 |
| InChIKey | IKDXDQDKCZPQSZ-JHYYTBFNSA-N |
| SMILES | CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6.CC(=O)O |
| Reference | </br>1:Goserelin acetate before transurethral resection of moderately enlarged benign prostatic hyperplasia: Prospective randomised-controlled clinical trial. Abo El-Enen M, Tawfik A, El-Abd AS, Ragab M, El-Abd S, Elrashidy M, Elmashad N, Rasheed M, El-Abd S.Arab J Urol. 2016 Mar;14(1):59-65. doi: 10.1016/j.aju.2015.09.007. Epub 2015 Nov 21. PMID: 26966595 Free PMC Article</br>2:[Giant subcutaneous hematoma with hemorrhagic shock induced by goserelin acetate injection for prostate cancer : report of a case]. Tashiro K, Kimura S, Naruoka T, Furuta N, Egawa S.Hinyokika Kiyo. 2014 Sep;60(9):455-8. Japanese. PMID: 25293802 Free Article</br>3:Both castration and goserelin acetate ameliorate myocardial ischemia reperfusion injury and apoptosis in male rats. Hadi NR, Yusif FG, Yousif M, Jaen KK.ISRN Pharmacol. 2014 Mar 4;2014:206951. doi: 10.1155/2014/206951. eCollection 2014. PMID: 24729888 Free PMC Article</br>4:Effects of treadmill training on combined goserelin acetate and doxorubicin-induced osteopenia in female rats. Hydock DS, Parry TL, Wymore JD, Iwaniec UT, Turner RT, Schneider CM, Hayward R.J Musculoskelet Neuronal Interact. 2014 Mar;14(1):10-8. PMID: 24583536 Free Article</br>5:[Ice application for reducing pain associated with goserelin acetate injection]. Ishii K, Nagata C, Koshizaki E, Nishiuchi S.Gan To Kagaku Ryoho. 2013 Oct;40(10):1361-3. Japanese. PMID: 24105059 </br>6:A case of delivery of healthy infant in breast cancer patient incidentally treated with goserelin acetate and tamoxifen during pregnancy. Ishizuka S, Satou S.Breast Cancer. 2016 Jan;23(1):164-6. doi: 10.1007/s12282-013-0469-z. Epub 2013 May 1. PMID: 23636905 </br>7:Preoperative endocrine therapy with goserelin acetate and tamoxifen in hormone receptor-positive premenopausal breast cancer patients. Shimizu D, Ishikawa T, Tanabe M, Sasaki T, Ichikawa Y, Chishima T, Endo I.Breast Cancer. 2014 Sep;21(5):557-62. doi: 10.1007/s12282-012-0429-z. Epub 2012 Nov 25. PMID: 23184499 </br>8:Stimulation of a non-functioning pituitary macroadenoma after administration of goserelin acetate for locally advanced prostate cancer causing a sustained elevation in PSA and testosterone. Youssef FR, Robinson RT, Boucher NR.Can Urol Assoc J. 2012 Apr;6(2):E84-6. doi: 10.5489/cuaj.11126. PMID: 22511442 Free PMC Article</br>9:Ten-year follow-up of neoadjuvant therapy with goserelin acetate and flutamide before radical prostatectomy for clinical T3 and T4 prostate cancer: update on Southwest Oncology Group Study 9109. Berglund RK, Tangen CM, Powell IJ, Lowe BA, Haas GP, Carroll PR, Canby-Hagino ED, deVere White R, Hemstreet GP 3rd, Crawford ED, Thompson IM Jr, Klein EA.Urology. 2012 Mar;79(3):633-7. doi: 10.1016/j.urology.2011.11.019. PMID: 22386416 Free PMC Article</br>10:[Effect of local cooling at injection site of goserelin acetate for pain relief]. Nukui A, Morita T.Gan To Kagaku Ryoho. 2011 Jun;38(6):967-72. Japanese. PMID: 21677488 |
